Donor Specific Antibody – Mediated Rejection in Allogeneic Hematopoietic Stem Cell Transplant Recipients
نویسنده
چکیده
Graft rejection remains a significant concern after hematopoietic stem, cell transplantation (HSCT). While its incidence and predisposing factors are well known in the setting of solid organ transplantation (SOT), the study of graft rejection still remains an area of active investigation in case of HSCT. Recipient T cells, natural killer cells and antibodies are implicated in graft rejection. Other factors that can contribute towards it are HLA mismatch, reduced intensity conditioning and hematopoietic stem cell dose [1].
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